Epigenetic Mechanisms in Gene Regulation
Unlocking the Hidden Code: The Power of Epigenetics in Gene Regulation
Skills you will gain:
The Epigenetic Mechanisms in Gene Regulation program provides a detailed examination of how epigenetic changes can control gene activity and the implications this has for human health and development. Throughout this one-month course, students will delve into the core concepts of DNA methylation, histone modification, and RNA-associated silencing, which collectively contribute to the dynamic regulation of gene expression.
Aim: This program seeks to explore the complex world of epigenetics, emphasizing how environmental factors can influence gene expression without altering the DNA sequence. Participants will learn to dissect the mechanisms of epigenetic regulation, their implications in health and disease, and the potential for epigenetic therapies.
Program Objectives:
- Understand the fundamentals of epigenetic modifications and their roles in gene regulation.
- Learn about the techniques used to study epigenetic changes, such as bisulfite sequencing and chromatin immunoprecipitation.
- Examine the impact of lifestyle and environmental factors on epigenetic patterns.
- Discuss the implications of epigenetics in disease manifestation and treatment.
- Explore the ethical and social issues related to epigenetic knowledge, especially in prenatal and predictive testing.
What you will learn?
Module 1: Introduction to Epigenetics
- Fundamentals of Gene Regulation
- Historical Perspective and Evolution of Epigenetics
Module 2: Key Epigenetic Mechanisms
- DNA Methylation
- Histone Modification
- RNA-associated Silencing
Module 3: Techniques in Epigenetic Research
- Chromatin Immunoprecipitation (ChIP)
- Bisulfite Sequencing
- CRISPR/Cas9-based Epigenome Editing
Module 4: Epigenetics in Development and Disease
- Epigenetics in Embryonic Development
- Epigenetics and Cancer
- Neuroepigenetics and Behavioral Epigenetics
Module 5: Therapeutic Applications and Future Directions
- Epigenetic Drugs (e.g., HDAC inhibitors, DNA methyltransferase inhibitors)
- Future of Epigenetic Therapy
Module 6: Ethical and Social Considerations
- Ethical Issues in Epigenetic Interventions
- Epigenetics and Society
Intended For :
- Undergraduate degree in Biology, Genetics, Biochemistry, or related fields.
- Professionals in biomedical, clinical research, or pharmaceutical industries.
- Individuals with a keen interest in genetic research and molecular biology.
Career Supporting Skills
