Workshop on Protein-Protein Interaction (PPI) Network Design and Structure
Connecting Proteins, Unveiling Pathways, Advancing Science
Virtual (Google Meet)
Mentor Based
Moderate
3 Days (1.5 hours per day)
18 -February -2025
3:00 PM IST
About
The workshop on Protein-Protein Interaction (PPI) Network Design and Structure is crafted for students, researchers, and professionals in the life sciences, biotechnology, and pharmaceutical industries. It emphasizes the significance of PPI networks in understanding cellular processes, signaling pathways, and disease mechanisms. Participants will gain a comprehensive understanding of bioinformatics tools used for PPI network construction, analysis, and functional annotation to drive innovations in therapeutic target identification and drug development.
Aim
To provide participants with the theoretical foundation and practical skills to construct, analyze, and interpret protein-protein interaction networks, fostering advancements in molecular biology, disease research, and systems biology.
Workshop Objectives
- Introduce the concept and biological significance of protein-protein interaction networks.
- Equip participants with hands-on experience in constructing PPI networks using cutting-edge tools.
- Teach participants to analyze PPI networks to identify key hub proteins and their biological roles.
- Facilitate the understanding of functional enrichment and its integration with PPI networks.
Workshop Structure
Day 1: Basics of PPI and Target Data Retrieval
Introduction to PPI Networks
- Overview of protein-protein interactions and their importance in biological systems
- Insights into the applications of PPI networks in disease research and drug discovery
Target Data Retrieval for PPI Networks
- Accessing databases like STRING
- Techniques for filtering and preprocessing PPI data
Hands-On Session
- Practical demonstration of target data retrieval
- Organizing and preparing data for PPI network construction
Day 2: Network Construction and Centrality Analysis
Building PPI Networks
- Using Cytoscape and STRING for network construction
- Importing and visualizing PPI data
Network Analysis Using CytoNCA
- Introduction to centrality metrics: degree centrality, closeness centrality, betweenness centrality
- Identifying hub proteins and key network nodes
Hands-On Session
- Step-by-step network construction with Cytoscape
- Practical exercises on network analysis and interpretation
Day 3: Functional Enrichment and Advanced Visualization
Gene Ontology (GO) and Pathway Analysis
- Introduction to GO terms and KEGG pathways
- Understanding functional enrichment analysis
Functional Enrichment with ClueGO
- Setting up the ClueGO plugin in Cytoscape
- Configuring and interpreting enrichment results
Advanced Visualization Techniques
- Improving PPI network visualization for publication
- Integrating enriched biological functions into the network
Hands-On Session
- Practical implementation of GO and pathway enrichment analysis
- Finalizing a PPI network for research or presentation purposes
Requirements
- Hardware: Windows PC or laptop with stable internet connection
- Software:
- Cytoscape (latest version)
- Plugins: ClueGO, CytoNCA
- Access to PPI databases (e.g., STRING)
Participant’s Eligibility
- Undergraduate or graduate degree in Biotechnology, Bioinformatics, Life Sciences, or related fields.
- Professionals from the pharmaceutical, healthcare, and biotechnology industries.
- Researchers with an interest in molecular biology, disease research, and systems biology.
Important Dates
Registration Ends
2025-02-18
Indian Standard Timing 2:00 PM
Workshop Dates
2025-02-18 to 2025-02-20
Indian Standard Timing 3:00 PM
Workshop Outcomes
- Proficiency in constructing and analyzing protein-protein interaction networks.
- Identification of key hub proteins and their biological significance.
- Mastery in functional enrichment analysis and pathway integration.
- Advanced visualization skills for publication-ready PPI networks.
- Competence in using Cytoscape and its plugins for research purposes.
Mentor Profile
Designation: Professional researcher
Affiliation: Jaypee Institute of Information Technology
Ms. Aaysha Gupta is a Research Scholar in the Biotechnology Department at Jaypee Institute of Information Technology. She is pursuing a PhD in Medical Biotechnology, with a focus on exploring the anti-aging potential of Indian medicinal plants. Ms. Gupta has previously held the positions of Editor and Event Organizer at Microbioz Journals for two years. She brings over three years of dedicated research experience in the field of Medical Biotechnology, specializing in muscle aging.
Fee Structure
Student
INR. 1399
USD. 50
Ph.D. Scholar / Researcher
INR. 1699
USD. 55
Academician / Faculty
INR. 2199
USD. 60
Industry Professional
INR. 2699
USD. 85
List of Currencies
Key Takeaways
- Access to Live Lectures
- Access to Recorded Sessions
- e-Certificate
- Query Solving Post Workshop
Future Career Prospects
- Research roles in molecular biology and bioinformatics.
- Opportunities in drug discovery and therapeutic target identification.
- Careers in systems biology and computational biology.
- Positions in biotech and pharmaceutical industries as bioinformaticians.
- Academic and industrial research focusing on disease mechanisms.
- Expertise applicable in precision medicine and personalized healthcare.
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