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Workshop Registration End Date :2025-01-08

Virtual Workshop

Advanced Workshop on CAR-T Therapy: Oncology and Beyond

Advancing CAR-T Therapy: From Oncology to Novel Applications

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MODE
Virtual (Google Meet)

TYPE
Mentor Based

LEVEL
Advanced

DURATION
3 Days (1.5 Hours/ Day)

Start Date
8 -January -2025

Time
03:00 PM IST

About

CAR-T therapy has revolutionized the field of oncology, offering personalized and highly effective treatments for certain cancers. This 3-day workshop dives deep into the biological principles behind CAR-T therapy, from T-cell engineering to antigen targeting, along with real-world applications and case studies in oncology. Participants will explore the full therapeutic landscape, including FDA-approved therapies and emerging treatments.
Beyond oncology, CAR-T therapy is now being explored for autoimmune diseases, infectious diseases, and other non-cancerous conditions. The workshop will discuss the future directions of CAR-T research and clinical trials, addressing the current hurdles in scaling these therapies. Participants will also engage in sessions, including CAR-T cell manufacturing, regulatory frameworks, and understanding the ethical considerations surrounding gene editing and cellular therapies.

Aim

This advanced workshop on “CAR-T Therapy: Oncology and Beyond” aims to provide a comprehensive understanding of Chimeric Antigen Receptor (CAR) T-cell therapy, its mechanisms, clinical applications, and future potential beyond oncology. Participants will gain insights into the latest developments, challenges, and innovations in CAR-T therapy for both cancer treatment and other emerging applications.

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Workshop Objectives

Understand the fundamentals of CAR-T cell biology and immunotherapy mechanisms.
Explore CAR-T therapy applications in oncology and beyond.
Learn about the latest innovations, clinical trials, and emerging applications.
Gain knowledge of CAR-T cell manufacturing and regulatory requirements.
Discuss ethical, safety, and scalability challenges in CAR-T therapy.

Workshop Structure

Day 1: Introduction to CAR-T Therapy

Workshop Overview

Introduction to the workshop structure and objectives
Importance of CAR-T therapy in modern oncology

Introduction to Immunotherapy

What is immunotherapy?
The role of the immune system in cancer treatment
Overview of different immunotherapy approaches (Monoclonal antibodies, checkpoint inhibitors, CAR-T)

CAR-T Therapy Basics

What is CAR-T (Chimeric Antigen Receptor T-cell) therapy?
Mechanism of CAR-T: How it works (T-cell modification and cancer cell targeting)
Historical development of CAR-T therapy
Overview of FDA-approved CAR-T therapies (e.g., Kymriah, Yescarta, Breyanzi)

The Science Behind CAR-T

T-cell biology and role in immune response
CAR-T cell structure and function: Antigen recognition, CAR components
Process of CAR-T cell therapy (from patient cell collection to infusion)

Clinical Indications of CAR-T Therapy

Types of cancers treated with CAR-T (leukemia, lymphoma, etc.)
Patient selection and eligibility criteria
Success rates and key clinical outcomes

Q&A and Recap

Open floor for questions
Summary of key learnings from Day 1

Day 2: CAR-T Therapy Manufacturing and Clinical Applications

Recap of Day 1 and Key Takeaways

Brief review of the fundamentals of CAR-T therapy

CAR-T Manufacturing Process

Overview of the CAR-T cell production process
Steps: T-cell collection, genetic modification (viral vectors), CAR-T expansion, and infusion
Challenges in manufacturing (scalability, cost, and logistics)
Ensuring safety and efficacy during production
Automation and emerging trends in CAR-T manufacturing

Clinical Administration of CAR-T Therapy

Patient preparation: Lymphodepleting chemotherapy
The CAR-T infusion process
Managing side effects and toxicities: Cytokine Release Syndrome (CRS), Neurotoxicity
CAR-T monitoring and patient management post-infusion
Long-term follow-up and remission rates

Real-World Case Studies

Analysis of real-world CAR-T patient outcomes (success stories and challenges)
Discussion of clinical trials and their significance in CAR-T advancements
Case study presentations with interactive Q&A

Q&A and Recap

Address any questions
Summarize the session learnings

Day 3: Future Directions, Challenges, and Ethical Considerations

Recap of Day 2 and Key Takeaways

Brief review of the CAR-T manufacturing and clinical process

Advancements and Innovations in CAR-T

Next-generation CAR-T therapies: Dual-targeting CARs, armored CARs, and universal CAR-T cells
CAR-NK and other cellular therapies in development
Use of CAR-T beyond hematologic malignancies (solid tumors)
Emerging technology: CRISPR and gene editing in CAR-T optimization

Overcoming Current Challenges

Resistance to CAR-T therapy and relapse in patients
Addressing high costs and accessibility issues
Managing side effects more effectively
Overcoming the complexity of treating solid tumors

Ethical and Regulatory Considerations

Ethical challenges in gene-modified therapies (access, cost, and equity)
Informed consent and patient education
Regulatory pathways for CAR-T approval (FDA, EMA)
Impact of CAR-T on the healthcare system (insurance coverage, cost of care)

Future of CAR-T: Looking Ahead

Predictions for the next 5–10 years in CAR-T therapy
Personalized medicine and the integration of AI and data in CAR-T treatment
Potential for CAR-T in combination therapies

Open Discussion and Q&A

Group discussion on the future of CAR-T
Audience questions and expert responses

Conclusion and Wrap-Up

Recap of the entire 3-day workshop
Final thoughts and takeaways

Participant’s Eligibility

Undergraduate or graduate degree in Biotechnology, Immunology, Biomedical Sciences, or related fields.
Medical professionals, oncologists, and clinical researchers involved in cell-based therapies.
Individuals with an interest in gene therapy, cellular therapies, or advanced medical treatments.

Important Dates

Registration Ends

2025-01-08
Indian Standard Timing 02:00 PM

Workshop Dates

2025-01-08 to 2025-01-10
Indian Standard Timing 03:00 PM

Workshop Outcomes

Master CAR-T cell biology and engineering principles.
Gain insights into the clinical applications of CAR-T therapies in cancer and other diseases.
Understand the regulatory and ethical frameworks governing CAR-T therapies.
Acquire skills in CAR-T cell manufacturing and quality control.
Explore future innovations and applications of CAR-T beyond oncology.

Mentor Profile

Fee Structure

Student

INR. 1399
USD. 50

Ph.D. Scholar / Researcher

INR. 1699
USD. 55

Academician / Faculty

INR. 2199
USD. 60

Industry Professional

INR. 2699
USD. 85

We are excited to announce that we now accept payments in over 20 global currencies, in addition to USD. Check out our list to see if your preferred currency is supported. Enjoy the convenience and flexibility of paying in your local currency!
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