Computer Aided Drug Design in Taste Masking (CADD)
Computer-Aided Drug Design, Taste Masking, Pharmaceutical Development, Patient Compliance, Formulation Approaches, Bitter Taste Modulation, Taste Receptor Interactions, In Silico Models
About Program:
Aim: The aim of the “Computer Aided Drug Design in Taste Masking (CADD)” program is to utilize computational methods and modeling techniques to design pharmaceutical compounds with improved taste masking properties. By leveraging computer-aided drug design (CADD) approaches, the program seeks to identify and optimize candidate molecules that effectively mask the bitter taste of pharmaceutical drugs, making them more palatable and acceptable for patients, particularly in pediatric or geriatric populations. Through a combination of molecular modeling, virtual screening, and structure-activity relationship (SAR) analysis, the program aims to expedite the discovery and development of taste-masked formulations, ultimately enhancing patient compliance, adherence to medication regimens, and therapeutic outcomes.
Program Objectives:
- Provide an overview of taste masking challenges in drug development and the importance of patient-centric formulation approaches.
- Introduce participants to the principles and techniques of computer-aided drug design and its application in taste masking.
- Share insights into the latest computational tools, methodologies, and software platforms used in taste masking studies.
- Highlight successful case studies and real-world examples where CADD has facilitated the development of palatable medications.
- Foster collaboration and knowledge exchange among participants from academia, industry, and regulatory bodies.
- Identify future research directions and opportunities in the field of taste masking through CADD.
What you will learn?
Day 1: Introduction to Computer-Aided Drug Design and Taste Masking
Basics of Drug Design and Taste Masking
- Introduction to computer-aided drug design (CADD) and its applications in pharmaceutical research
- Overview of taste masking techniques and their importance in enhancing patient acceptability
- Challenges and considerations in taste masking of pharmaceutical compounds
Principles of Taste Perception and Evaluation
- Understanding the physiology of taste perception
- Techniques for evaluating taste perception and masking efficacy
- Case studies highlighting successful taste masking strategies
Computational Techniques in Drug Design
- Introduction to molecular modeling and simulation methods
- Structure-based drug design approaches for taste masking
- Virtual screening and ligand-based drug design techniques
Day 2: Computational Tools and Techniques for Taste Masking
Molecular Docking and Binding Analysis
- Principles of molecular docking and its role in predicting drug-target interactions
- Hands-on session using molecular docking software to identify potential taste masking agents
In Silico Formulation Design and Optimization
- Overview of in silico formulation design techniques
- Predictive modeling for optimizing drug release and taste masking in different dosage forms
- Case studies illustrating successful in silico formulation design approaches
Day 3: Case Studies
Case Studies on Taste Masking in Various Drug Delivery Systems
- Application of computer-aided drug design in taste masking for oral solid dosage forms, liquids
- Evaluation of taste masking efficacy using computational methods
Interactive Discussion and Future Trends
- Open forum for participants to share their experiences and challenges in taste masking research
- Discussion on emerging trends and future directions in computer-aided taste masking
Fee Plan
Intended For :
- Educational Background: Participants may be required to have a background in pharmaceutical sciences, medicinal chemistry, pharmacology, computational chemistry, or a related field at the undergraduate or graduate level.
- Research Experience: Some programs may prefer participants with prior research experience in drug design, computational chemistry, pharmaceutical formulation, or taste masking techniques.
- Computer Skills: Proficiency in computer programming languages (e.g., Python, R), molecular modeling software (e.g., Schrödinger, MOE, AutoDock), and statistical analysis tools may be beneficial for effective participation in the program.
- Interest and Motivation: Individuals with a strong interest in drug discovery, pharmaceutical formulation, and computational methods, as well as a commitment to advancing their skills and knowledge in these areas, are typically encouraged to apply.
- Language Proficiency: Depending on the language of instruction and communication, participants may be required to demonstrate proficiency in the relevant language(s), typically English.
Career Supporting Skills
Program Outcomes
- In-depth Understanding of Taste Masking Principles
- Knowledge of Computer-Aided Drug Design (CADD) Techniques
- Familiarity with Innovative Taste Masking Strategies
- Insight into Current Research and Advancements
- Improved Drug Formulation and Patient Adherence
