Aim
Diabetes Drug Delivery: Creating Therapy for Diabetes covers drug delivery methods used to improve diabetes care. Learn therapy basics, delivery routes, long-acting formulations, smart delivery concepts, testing, and a capstone design plan.
Program Objectives
- Diabetes Basics: Type 1/Type 2 and glucose control.
- Therapies: insulin, GLP-1, oral agents (overview).
- Routes: oral, injectable, transdermal, nasal, implantable.
- Formulations: sustained release and depot systems.
- Micro/Nano Systems: carriers and protection of peptides.
- Smart Delivery: glucose-responsive concepts.
- Testing: stability, release, PK/PD basics, safety.
- Capstone: delivery strategy design.
Program Structure
Module 1: Diabetes and Treatment Goals
- Insulin deficiency vs insulin resistance (overview).
- Monitoring concepts and outcome measures.
- Why delivery affects control and adherence.
- Short-acting vs long-acting therapy goals.
Module 2: Diabetes Drugs
- Insulin types and dosing concepts.
- GLP-1 receptor agonists (overview).
- Oral drugs: metformin, SGLT2, DPP-4 (overview).
- Stability issues: peptides vs small molecules.
Module 3: Delivery Routes and Barriers
- Oral delivery barriers for peptides.
- Subcutaneous delivery and absorption basics.
- Microneedles and transdermal delivery (intro).
- Implants and long-acting systems (intro).
Module 4: Sustained Release Formulations
- Release kinetics concepts.
- Polymer depots and microspheres (overview).
- Hydrogels and in situ gels (intro).
- Stability and cold-chain basics.
Module 5: Micro/Nano Drug Delivery (Intro)
- Lipid nanoparticles, polymer nanoparticles, nanoemulsions (overview).
- Encapsulation and protection of peptides.
- Targeting concepts (overview).
- Safety and clearance basics.
Module 6: Smart Delivery and Devices
- Glucose-responsive delivery concepts.
- Stimuli-responsive materials (intro).
- CGM + pump closed-loop overview.
- Usability and dosing safety basics.
Module 7: Testing and Translation
- In-vitro tests: release, stability, compatibility.
- PK/PD and bioavailability basics.
- Biocompatibility and immunogenicity (overview).
- Scale-up constraints (overview).
Module 8: Case Studies and Design Plan
- Long-acting injectables and device-linked therapy (overview).
- Risks: hypoglycemia, variability, dose dumping.
- Endpoints: HbA1c, time-in-range, safety markers.
- Short product concept brief.
Final Project
- Select a therapy and delivery route.
- Deliverables: formulation plan + release goal + testing plan + safety checklist.
- Submit: short design dossier.
Participant Eligibility
- Students/professionals in Pharmacy, Biotechnology, Biomedical Engineering
- Researchers in formulation and drug delivery
- Basic pharmaceutics helpful
Program Outcomes
- Understand diabetes therapy and delivery routes.
- Choose sustained release strategies.
- Plan testing and safety checks.
- Create a delivery design dossier.
Program Deliverables
- e-LMS Access: lessons, templates.
- Toolkit: formulation sheet, testing checklist.
- Assessment: certification after submission.
- e-Certification and e-Marksheet: digital credentials.
Future Career Prospects
- Drug Delivery Research Associate
- Formulation Scientist (Trainee)
- Pharma R&D Associate
- Biomedical Product Development Trainee
Job Opportunities
- Pharma: diabetes formulation and delivery teams.
- Biotech: peptide delivery platforms.
- CROs: formulation and characterization services.
- Devices: pumps, injectors, delivery systems.
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