Aim

The Cancer Drug Discovery: Creating Cancer Therapies course provides a comprehensive overview of cancer drug discovery, from target identification to clinical trials. Learn about molecular targets, preclinical testing, clinical phases, and the role of emerging technologies such as immunotherapy, personalized medicine, and targeted therapies in the fight against cancer.

Program Objectives

Cancer Biology Basics: Understanding cancer pathophysiology and molecular targets.
Drug Discovery Process: Identifying targets, lead compounds, and optimizing drug candidates.
Preclinical Testing: In vitro and in vivo models for efficacy and safety testing.
Clinical Development: Phases of clinical trials, regulatory approval, and commercialization.
Emerging Therapies: Immunotherapy, gene therapy, and personalized cancer treatments.
Challenges in Cancer Drug Discovery: Drug resistance, targeting multiple pathways, and patient heterogeneity.
Capstone: Design a cancer drug development strategy for a specific target.

Program Structure

Module 1: Introduction to Cancer Biology

Overview of cancer biology: hallmarks of cancer, tumor microenvironment.
Common cancer types: breast, lung, colorectal, and others.
Genetic mutations and molecular pathways involved in cancer progression.

Module 2: Target Identification and Validation

Identifying molecular targets: receptors, enzymes, and signaling pathways.
In silico tools for target prediction and validation.
Experimental approaches for validating drug targets in cancer research.

Module 3: Drug Discovery Strategies

High-throughput screening for lead compound identification.
Structure-based drug design and virtual screening techniques.
Hit-to-lead optimization: ADMET properties and structure-activity relationship (SAR).

Module 4: Preclinical Testing and Animal Models

Preclinical models: in vitro assays and in vivo models for testing drug efficacy.
Pharmacokinetics and pharmacodynamics in animal models.
Toxicology testing and safety evaluations for cancer drugs.

Module 5: Clinical Trials and Development

Phases of clinical trials: Phase I, II, III, and IV.
Endpoints, patient selection, and trial design for cancer drugs.
Regulatory approval process: FDA, EMA guidelines for cancer drugs.

Module 6: Emerging Therapies in Cancer Treatment

Immunotherapy: checkpoint inhibitors, CAR-T cell therapy, and cancer vaccines.
Gene therapy and CRISPR technology in cancer treatment.
Personalized medicine: biomarkers and targeted therapies in precision oncology.

Module 7: Overcoming Drug Resistance

Mechanisms of drug resistance in cancer: genetic mutations, epigenetics, and microenvironmental factors.
Combination therapies: targeting multiple pathways to overcome resistance.
Emerging strategies for re-sensitizing tumors to chemotherapy and targeted therapies.

Module 8: Challenges and Future Directions in Cancer Drug Discovery

Challenges in cancer drug development: safety, efficacy, and patient variability.
Novel drug delivery systems for improving bioavailability and targeting.
Future trends: AI and machine learning in cancer drug discovery.

Final Project

Design a cancer drug development strategy for a chosen target or cancer type.
Deliverables: target identification, drug discovery strategy, preclinical testing plan, and clinical trial roadmap.
Submit: project report and presentation summarizing the drug development process.

Participant Eligibility

Students and professionals in Pharmaceutical Sciences, Biotechnology, Molecular Biology, Biomedical Engineering
Researchers working on cancer therapeutics and drug discovery
Basic knowledge of cancer biology and drug development is recommended

Program Outcomes

Understand cancer biology and therapeutic targets for drug development.
Learn the drug discovery process, from target identification to clinical trials.
Design and evaluate cancer therapies using preclinical and clinical approaches.
Apply emerging technologies such as immunotherapy and personalized medicine in cancer treatment.

Program Deliverables

e-LMS Access: lessons, case studies, templates, and tools.
Toolkit: drug discovery guides, target validation templates, clinical trial planning tools.
Capstone Support: feedback on drug discovery strategy and development plan.
Assessment: certification after final project submission.
e-Certification and e-Marksheet: digital credentials upon completion.

Future Career Prospects

Cancer Drug Discovery Researcher
Pharmaceutical Development Associate (Cancer Therapeutics)
Oncology Research Scientist
Clinical Trials Manager (Cancer Drugs)

Job Opportunities

Pharmaceutical Companies: cancer drug discovery and development teams.
Biotech: research and development in cancer therapeutics.
Contract Research Organizations (CROs): clinical trial support and cancer research services.
Academia: cancer biology research and therapeutic studies.

Category	E-LMS, E-LMS+Videos, E-LMS+Videos+Live Lectures

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Cancer Drug Discovery: Creating Cancer Therapies Course

Aim

Program Objectives