Next-Generation CAR-T Therapies: From Laboratory Discoveries to Industry Solutions
Engineering the Future of Cancer Treatment—Next-Gen CAR-T from Bench to Biotech
About This Course
Chimeric Antigen Receptor (CAR)-T cell therapy has revolutionized cancer treatment, especially in hematological malignancies. However, challenges such as cytokine release syndrome (CRS), neurotoxicity, limited persistence, antigen escape, and manufacturing complexity have driven the development of next-generation CAR designs. Innovations include dual-target CARs, armored CAR-T cells, logic-gated systems, and gene-edited universal CAR platforms aimed at improving safety, efficacy, and accessibility.
This workshop explores the entire CAR-T development pipeline—from target identification and vector design to cell expansion, quality control, regulatory pathways, and commercialization strategies. Participants will understand translational bottlenecks, GMP manufacturing considerations, and emerging off-the-shelf CAR-T platforms. The program emphasizes industry relevance, regulatory compliance, and scalable solutions for the future of advanced cell therapies.
Aim
This workshop aims to provide a comprehensive understanding of next-generation CAR-T cell therapies, from fundamental laboratory research to scalable industry applications. It focuses on engineering strategies, safety enhancements, and translational workflows that drive modern cell therapy innovation. Participants will explore how CAR-T platforms are evolving to address solid tumors, toxicity challenges, and manufacturing scalability. The program bridges immunotherapy science with industrial bioprocess and regulatory frameworks.
Workshop Objectives
- Understand CAR-T cell engineering principles and antigen targeting strategies.
- Explore next-generation CAR constructs (dual CARs, armored CARs, logic-gated CARs).
- Learn about GMP manufacturing workflows and scalability challenges.
- Analyze toxicity management and safety switch mechanisms.
- Discuss regulatory pathways and commercialization of advanced cell therapies.
Workshop Structure
Day 1: CAR-T Cell Engineering & Target Discovery
- Overview of CAR-T therapy evolution and next-generation innovations
- Structure of CAR constructs (scFv, hinge, transmembrane, co-stimulatory domains)
- Tumor antigen selection strategies (CD19, BCMA, HER2, novel solid tumor targets)
- Tumor microenvironment challenges and immune escape mechanisms
- Vector systems: Lentiviral vs Retroviral vs Non-viral approaches
- CRISPR-based genome editing in CAR-T optimization
- Tools: GEPIA / TCGA portals (demo), NCBI GEO datasets, SnapGene (vector visualization demo), Benchling (construct design overview), CRISPR design tools
Day 2: Manufacturing, Bioinformatics & Quality Control in CAR-T Development
- CAR-T cell manufacturing workflow (Leukapheresis → Engineering → Expansion → Infusion)
- GMP considerations and scalability challenges
- Single-cell RNA sequencing in CAR-T profiling
- Monitoring cytokine release syndrome (CRS) biomarkers
- Flow cytometry data interpretation for CAR-T validation
- Biostatistics in clinical trial response assessment
- Tools: Python (Google Colab) or R, Pandas / DESeq2 (conceptual), FlowJo (demo overview), GraphPad Prism (data visualization demo), Seaborn/Matplotlib
Day 3: Advanced CAR-T Innovations & Industry Translation
- Next-generation CAR designs (Dual CAR, Tandem CAR, Armored CAR, Universal CAR-T)
- Allogeneic vs Autologous CAR-T strategies
- AI integration in CAR-T target discovery and toxicity prediction
- CAR-T applications in solid tumors and autoimmune diseases
- Regulatory pathways (IND, FDA/EMA overview)
- Commercialization strategies and biotech startup landscape
- Cost optimization and market access challenges
- Tools: ClinicalTrials.gov (data exploration), Python ML libraries (Scikit-learn – conceptual demo), TCGA portal, BioRender (design conceptualization), Regulatory guideline resources
Who Should Enrol?
- Doctoral Scholars & Researchers: PhD candidates seeking to integrate computational workflows into their molecular research.
- Postdoctoral Fellows: Early-career scientists aiming to enhance their data-driven publication profile.
- University Faculty: Professors and HODs interested in modern bioinformatics pedagogy and tool mastery.
- Industry Scientists: R&D professionals from the Biotechnology and Pharmaceutical sectors transitioning to genomic-driven discovery.
- Postgraduate Students: Final-year PG students looking for specialized research-grade exposure beyond standard curricula.
Important Dates
Registration Ends
02/24/2026
IST 7:00 PM
Workshop Dates
02/24/2026 – 02/26/2026
IST 8:00 PM
Workshop Outcomes
Participants will be able to:
- Explain next-generation CAR-T engineering strategies.
- Understand challenges in safety, efficacy, and scalability.
- Describe GMP and industrial workflows for CAR-T production.
- Evaluate translational and regulatory pathways for cell therapies.
- Identify emerging industry trends in immunotherapy innovation.
Fee Structure
Student Fee
₹1699 | $65
Ph.D. Scholar / Researcher Fee
₹2699 | $75
Academician / Faculty Fee
₹3699 | $90
Industry Professional Fee
₹4699 | $100
What You’ll Gain
- Live & recorded sessions
- e-Certificate upon completion
- Post-workshop query support
- Hands-on learning experience
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