CRISPR for Cancer Genomics: A Hands-On Workshop
Edit the Genome, Decode the Cure: CRISPR Meets Cancer Genomics
About This Course
Cancer genomics and CRISPR-Cas9 technologies are reshaping modern biomedical research. This intensive 3-day workshop provides a unique platform to understand the intersection of these two revolutionary domains. Participants will explore the principles of target gene identification using TCGA/COSMIC databases, design optimized gRNAs with tools like CRISPOR and CHOPCHOP, and address off-target concerns crucial for precision genome editing.
The workshop combines theoretical modules with lab-simulated hands-on sessions, covering delivery strategies using viral and non-viral vectors, functional genomic screening with MAGeCK and PinAPL-Py, and post-screening analysis using CRISPResso and IGV. Ethical considerations and data integration practices are also discussed, preparing participants for translational cancer genomics research or industry-oriented roles.
Aim
This hands-on workshop aims to equip participants with in-depth knowledge and practical skills to harness CRISPR-Cas9 for cancer research. Through guided tutorials, real-data walkthroughs, and bioinformatics tools, participants will explore gene editing for functional genomics, target validation, and personalized oncology applications.
Workshop Objectives
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Understand gene selection from cancer genome databases (TCGA/COSMIC)
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Design gRNAs using leading online platforms with off-target validation
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Learn about CRISPR delivery strategies for mammalian systems
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Analyze CRISPR screening data using bioinformatics tools
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Integrate results for biological interpretation and ethical reporting
Workshop Structure
Day 1:Target Identification and gRNA Design
- Target gene selection (TCGA/COSMIC)
- Off-target prediction and design (CRISPOR, CHOPCHOP)
- Hands-on: Guide RNA design
Day 2: Delivery Systems and Functional Screening
- Viral/non-viral delivery (LentiGuide, AAV)
- Functional screening setup (MAGeCK, PinAPL-Py)
- Hands-on: Troubleshooting delivery
Day 3: Data Analysis and Validation
- Data analysis (MAGeCK, CRISPResso)
- Data integration and ethics (VMD, Integrative Genomics Viewer)
- Hands-on: Data analysis and validation
Who Should Enrol?
- Undergraduate/postgraduate degree in Biotechnology, Genetics, Biomedical Engineering, Bioinformatics, or related life sciences.
- Researchers and professionals working in genomics, oncology, and molecular biology domains.
- Individuals interested in CRISPR, cancer research, or translational genomics.
Important Dates
Registration Ends
08/02/2025
IST 2:00 PM
Workshop Dates
08/02/2025 – 08/04/2025
IST 3:00 PM
Workshop Outcomes
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Ability to identify and validate target genes in cancer datasets
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Skills to design and test effective gRNAs
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Understanding of CRISPR delivery tools and troubleshooting
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Proficiency in data analysis using MAGeCK, CRISPResso, IGV
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Familiarity with ethical and integrative aspects of cancer gene editing
Meet Your Mentor(s)
Fee Structure
Student Fee
₹1399 | $50
Ph.D. Scholar / Researcher Fee
₹1699 | $55
Academician / Faculty Fee
₹2199 | $60
Industry Professional Fee
₹2699 | $85
What You’ll Gain
- Live & recorded sessions
- e-Certificate upon completion
- Post-workshop query support
- Hands-on learning experience
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