In Silico Medicine: Ultrasonic Wave Propagation and Tissue Interaction

The aim of this research is to explore the interactions between ultrasonic wave propagation and biological tissues through in silico models. This will enhance non-invasive diagnostic accuracy, optimize therapeutic ultrasound treatments, and contribute to the development of personalized medicine by tailoring interventions based on tissue-specific responses.

• To model ultrasonic wave propagation in different biological tissues using in silico methods.
• To analyze the interaction between ultrasonic waves and tissue structures for improved diagnostic accuracy.
• To optimize therapeutic ultrasound techniques for targeted and effective treatments.
• To develop personalized medicine approaches by tailoring ultrasound therapies based on tissue-specific responses.
• To advance non-invasive diagnostic tools for clinical applications in medicine.

📅 Day 1 — Transducer Design & Beam Steering

• Piezoelectric Physics and Phased Arrays
• Fundamentals of Transducer Design
• Introduction to Beam Steering Mechanisms

Hands-on

• Scripting a Linear Transducer Array in k-Wave
• Implementing Time Delays for Beam Steering (45-degree Sector)
• Visualizing Beam Focusing

Deliverable

Wave-field Animation: Focused Beam Scanning a Sector

📅 Day 2 — Modeling Soft Tissue

• Acoustic Properties of Soft Tissues
• Non-Linearity in Wave Propagation
• Attenuation Power Laws
• The Role of Scatterers in Medical Ultrasound Imaging

Hands-on

• Creating a Phantom Map for Soft Tissue Layers (Skin, Fat, Muscle)
• Acoustic Speed Variations in Different Tissues

Deliverable

B-Mode Ultrasound Image Generated from Code

📅 Day 3 — Therapeutic Ultrasound (HIFU)

• High-Intensity Focused Ultrasound (HIFU) Fundamentals
• Mechanisms of Thermal Ablation and Tissue Interaction
• Clinical Applications of HIFU in Tumor Treatment

Hands-on

• Simulating a Focused Heat Deposition Map
• Virtual Tumor Targeting Using HIFU
• Protecting Surrounding Tissue during Treatment

Deliverable

Thermal Dose Map Confirming Virtual Tumor Destruction

• Doctoral Scholars & Researchers: PhD candidates seeking to integrate computational workflows into their molecular research.
• Postdoctoral Fellows: Early-career scientists aiming to enhance their data-driven publication profile.
• University Faculty: Professors and HODs interested in modern bioinformatics pedagogy and tool mastery.
• Industry Scientists: R&D professionals from the Biotechnology and Pharmaceutical sectors transitioning to genomic-driven discovery.
• Postgraduate Students: Final-year PG students looking for specialized research-grade exposure beyond standard curricula.

• Improved understanding of how ultrasonic waves interact with different tissue types.
• Development of advanced, non-invasive diagnostic techniques using ultrasound technology.
• Enhanced precision in targeting treatments with optimized therapeutic ultrasound models.
• Creation of personalized treatment plans based on tissue-specific ultrasonic wave responses.
• Contribution to the broader field of in silico medicine with applications in clinical settings.