Organoids & Organ-on-Chip Microphysiological Systems: Experimental Design, Validation & Preclinical Drug Testing
Design, validate, and interpret advanced human-relevant models for preclinical drug testing and toxicity assessment. Aim
About This Course
This 3-day hands-on workshop introduces participants to the complete experimental workflow, from selecting cell sources and designing organoid or organ-on-chip models to validating biological and engineering performance and interpreting drug-testing results.
Through practical exercises and real-world datasets, participants will evaluate model quality, analyze dose-response relationships, assess toxicity signals, and make evidence-based preclinical go/no-go decisions.
Aim
This workshop aims to provide participants with a practical understanding of how organoids, organ-on-chip platforms, and microphysiological systems are designed, validated, and applied in preclinical drug testing. Participants will learn how to select appropriate models, define experimental conditions, evaluate model quality, interpret dose-response data, and support preclinical decision-making.
Workshop Objectives
- Understand the principles of organoids, spheroids, organ-on-chip platforms, and microphysiological systems.
- Select appropriate cell sources, organ models, extracellular matrices, and experimental platforms.
- Design controls, replicates, exposure conditions, endpoints, and experimental workflows.
- Assess biological, functional, and engineering validation parameters.
- Evaluate morphology, biomarkers, barrier function, tissue-specific responses, reproducibility, and assay variability.
- Design drug exposure and concentration-response experiments.
- Interpret IC50, EC50, efficacy, toxicity, and organ-specific safety data.
- Integrate multiple biological and functional readouts for preclinical assessment.
- Translate MPS-derived data into evidence-based preclinical decisions.
Workshop Structure
Day 1 – Experimental Design of Organoids & Organ-on-Chip MPS
- Organoids, spheroids, organ-on-chip, and microphysiological systems
- Selecting cell source, organ model, and experimental platform
- Designing extracellular matrix, microenvironment, and perfusion conditions
- Controls, replicates, exposure duration, and endpoint selection
- Experimental workflow for preclinical studies
🛠️ Hands-On: Build a fit-for-purpose experimental design for a selected organoid or organ-on-chip model, including controls, exposure conditions and endpoints.
Day 2 – Validation & Quality Assessment
- Biological and functional validation of organoid models
- Engineering validation of organ-on-chip systems
- Morphology, biomarkers, barrier function and tissue-specific readouts
- Reproducibility, variability, and assay quality
- Fit-for-purpose validation for drug-testing applications
🛠️ Hands-On: Evaluate a model validation dataset using viability, biomarker, functional and variability metrics to determine whether the model meets predefined QC criteria.
Day 3 – Preclinical Drug Testing & Data Interpretation
- Drug exposure and dose-response experimental design
- Drug efficacy, toxicity, and organ-specific safety assessment
- IC50/EC50 and concentration-response interpretation
- Integrating viability, functional, and biomarker readouts
- Translating MPS results into preclinical decisions
🛠️ Hands-On: Analyze a liver organoid-on-chip drug-testing dataset, generate a dose-response curve, assess toxicity signals and make a preclinical go/no-go decision.
Who Should Enrol?
- Undergraduate and postgraduate students in Biotechnology, Biomedical Sciences, Life Sciences, Pharmacy, Bioengineering, and related disciplines.
- PhD scholars and research fellows working in organoids, tissue engineering, toxicology, pharmacology, regenerative medicine, or drug discovery.
- Faculty members and academic researchers interested in advanced in vitro models and microphysiological systems.
- Pharmaceutical, biotechnology, CRO, and preclinical research professionals involved in drug screening, efficacy testing, safety assessment, and toxicology.
- Researchers interested in alternatives to conventional animal models and human-relevant preclinical testing platforms.
Important Dates
Registration Ends
September 15, 2026
IST 4:30 PM
Workshop Dates
September 15, 2026 – September 17, 2026
IST 5:00 PM
Workshop Outcomes
- Design a fit-for-purpose organoid or organ-on-chip experiment.
- Select suitable controls, exposure conditions, endpoints, and validation criteria.
- Evaluate organoid and organ-on-chip models using predefined quality-control metrics.
- Interpret viability, biomarker, functional, and variability datasets.
- Generate and interpret drug concentration-response curves.
- Assess drug efficacy and toxicity using organ-specific readouts.
- Integrate multiple experimental endpoints for comprehensive drug assessment.
- Analyze liver organoid-on-chip drug-testing data and identify potential toxicity signals.
- Make scientifically justified preclinical go/no-go decisions based on MPS data.
Fee Structure
Student Fee
₹2499 | $65
Ph.D. Scholar / Researcher Fee
₹3499 | $75
Academician / Faculty Fee
₹4499 | $85
Industry Professional Fee
₹5499 | $105
What You’ll Gain
- Live & recorded sessions
- e-Certificate upon completion
- Post-workshop query support
- Hands-on learning experience
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