Aim
Medical Breakthroughs with Bionanotechnology: Applications and Innovations covers how nanoscale materials and bio-interfaces enable new diagnostics, therapies, and regenerative solutions. Learn core bionano concepts, platform design, characterization, safety basics, and a capstone innovation plan.
Program Objectives
- Bionano Basics: nano-bio interactions, surface chemistry, protein corona concepts.
- Diagnostics: nanosensors, biosensing, imaging probes (overview).
- Therapeutics: targeted delivery, photothermal/photodynamic concepts, nano-vaccines (overview).
- Regeneration: scaffolds, wound healing, tissue engineering concepts.
- Characterization: size, charge, morphology, stability, bio-testing basics.
- Safety: cytotoxicity, hemocompatibility, biodistribution concepts.
- Translation: scale-up, QC, documentation, regulatory basics.
- Capstone: design a bionanotech solution for a medical problem.
Program Structure
Module 1: Foundations of Bionanotechnology
- Why nano changes biology: size, surface area, targeting concepts.
- Bio-interfaces: adsorption, corona formation, immune recognition (intro).
- Common platforms: liposomes, LNPs, polymer NPs, metal/oxide NPs, hydrogels (overview).
- Design goals: stability, specificity, safety.
Module 2: Nano-Enabled Diagnostics
- Rapid tests and point-of-care sensing concepts.
- Electrochemical and optical biosensors (overview).
- Nanoparticles in imaging: contrast enhancement concepts.
- Signal amplification and detection limits (intro).
Module 3: Targeted Drug Delivery and Precision Therapy
- Targeting basics: passive vs active targeting.
- Controlled release: sustained and stimuli-responsive concepts.
- Cell uptake and intracellular delivery challenges.
- Case examples: cancer, infections, inflammation (overview).
Module 4: Photothermal, Photodynamic, and Theranostics
- Photothermal and photodynamic mechanisms (concepts).
- Theranostics: combined imaging + therapy workflows (intro).
- Light, dose, and safety constraints (overview).
- Designing evaluation experiments (intro).
Module 5: Nanovaccines and Immuno-Engineering (Overview)
- Antigen delivery and adjuvant concepts.
- LNP-based platforms and stability basics.
- Immune activation vs safety trade-offs.
- Measuring response: basic readouts (overview).
Module 6: Regenerative Medicine and Wound Healing
- Nanofibers, hydrogels, and scaffold concepts.
- Drug-loaded dressings and antimicrobial coatings (overview).
- Biocompatibility and degradation concepts.
- Basic in vitro testing plans.
Module 7: Characterization and Safety Testing
- Characterization: DLS, zeta, SEM/TEM concepts; stability studies.
- Bio-testing: cytotoxicity, hemolysis, uptake assays (overview).
- Biodistribution and clearance concepts.
- Risk controls: dose, route, material choice.
Module 8: Translation to Product
- Scale-up constraints and batch reproducibility.
- Quality basics: CQAs, release testing concepts.
- Documentation: SOP, COA, study report outline.
- Regulatory and ethics basics (research/clinical research context).
Final Project
- Select a medical problem (diagnosis, therapy, wound healing, imaging).
- Deliverables: platform choice + design rationale + test plan + safety checklist + short report.
- Submit: innovation dossier.
Participant Eligibility
- Students/professionals in Biotechnology, Biomedical Engineering, Pharmacy, Nanotechnology
- Researchers in diagnostics, drug delivery, biomaterials
- Basic biology and chemistry helpful
Program Outcomes
- Understand key bionano platforms and medical use cases.
- Plan design, characterization, and safety tests for nano systems.
- Evaluate feasibility for translation and manufacturing basics.
- Create a portfolio-ready bionanotech innovation dossier.
Program Deliverables
- e-LMS Access: lessons, templates.
- Toolkit: platform selection sheet, test checklist, report outline.
- Assessment: certification after submission.
- e-Certification and e-Marksheet: digital credentials.
Future Career Prospects
- Bionanotechnology Research Associate
- Nanomedicine Analyst (Entry-level)
- Biomedical R&D Associate
- Diagnostics Product Trainee
Job Opportunities
- Biotech/Pharma: nanomedicine and drug delivery R&D.
- Diagnostics: biosensors and point-of-care development teams.
- Hospitals/Research Centers: translational research labs.
- Universities: biomaterials and nanotechnology research groups.
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