Aim
Enhancing Drug Delivery Efficiency with Nano-Pharmaceuticals explains how nanoformulations improve solubility, stability, targeting, and controlled release. Learn nano-carrier selection, formulation design, characterization, safety basics, scale-up concepts, and a capstone delivery strategy plan.
Program Objectives
- Efficiency Goals: improve bioavailability, reduce dose, lower toxicity.
- Platforms: liposomes, LNPs, polymer nanoparticles, micelles, SLN/NLC, nanoemulsions.
- Targeting: passive/active targeting and ligand concepts.
- Release: sustained and stimuli-responsive release concepts.
- Characterization: size/PDI, zeta, loading, release, stability.
- Safety: biocompatibility, immune response, biodistribution concepts.
- Manufacturing: batch consistency, sterilization, lyophilization concepts.
- Capstone: build a nano-delivery plan for a selected drug.
Program Structure
Module 1: Why Nano-Pharmaceuticals Improve Delivery
- Delivery barriers: solubility, degradation, clearance, off-target effects.
- Efficiency metrics: exposure, targeting index, therapeutic window (intro).
- Formulation-to-clinical link: why size/surface matters.
- Case examples: oncology, antimicrobials, vaccines (overview).
Module 2: Nano-Carrier Platforms
- Liposomes and lipid nanoparticles: use cases and limits.
- Polymeric nanoparticles and micelles: loading and release logic.
- SLN/NLC and nanoemulsions: stability and formulation choices.
- Dendrimers and inorganic carriers (intro): when used and risks.
Module 3: Formulation Design for Efficiency
- Choosing excipients: lipids, polymers, surfactants (overview).
- Encapsulation: hydrophilic vs hydrophobic drugs.
- Process variables: mixing, ratios, temperature, shear.
- Stability planning: aggregation, oxidation, leakage.
Module 4: Targeting and Controlled Release
- Passive targeting and circulation-time concepts.
- Active targeting: ligand selection and attachment concepts.
- Stimuli-responsive release: pH/redox/enzymes/temperature (intro).
- Barrier crossing concepts: mucus, tumors, BBB (overview).
Module 5: Characterization and Performance Testing
- Size/PDI, zeta potential, morphology concepts.
- Drug loading, encapsulation efficiency, release profiling.
- Stability testing: stress, shelf-life, storage conditions.
- In-vitro models: uptake, permeability, hemocompatibility (overview).
Module 6: PK/PD, Biodistribution, and Safety
- How nanoformulations change ADME (concepts).
- Protein corona and immune recognition (intro).
- Toxicity basics: cytotoxicity, inflammation, complement activation (overview).
- Safety-by-design principles and risk controls.
Module 7: Scale-Up and Quality
- Reproducibility and batch consistency.
- Sterile processing, filtration limits, endotoxin control (overview).
- Lyophilization and reconstitution planning (intro).
- Quality basics: CQAs/CPPs and control strategy (intro).
Module 8: Product Strategy and Documentation
- Choosing route and dosage form: IV, oral, topical, inhalation (overview).
- Risk claims: what can and cannot be concluded from data.
- Simple CMC-style documentation: specs, tests, batch record (intro).
- Translational challenges: stability, scalability, variability.
Final Project
- Select a drug and define the delivery problem (solubility/toxicity/targeting).
- Deliverables: platform choice + formulation plan + test panel + safety checklist + short report.
- Submit: nano-delivery strategy dossier.
Participant Eligibility
- Students/professionals in Pharmacy, Biotechnology, Biomedical/Nanotechnology
- Researchers in formulation and drug delivery
- Basic pharmaceutics helpful
Program Outcomes
- Select nano-carriers based on drug and delivery goals.
- Plan formulation variables and characterization tests.
- Understand safety and scale-up constraints.
- Create a delivery strategy dossier.
Program Deliverables
- e-LMS Access: lessons, templates.
- Toolkit: carrier selection sheet, CQA/CPP template, test checklist, report outline.
- Capstone Support: feedback on dossier.
- Assessment: certification after submission.
- e-Certification and e-Marksheet: digital credentials.
Future Career Prospects
- Nanopharmaceutics Research Associate
- Formulation Scientist (Trainee)
- Drug Delivery R&D Associate
- Analytical Characterization Associate
Job Opportunities
- Pharma R&D: nanoformulation and drug delivery teams.
- Biotech: nanoparticle therapeutics and vaccines.
- CROs: formulation development and testing services.
- Academic Labs: translational drug delivery research.
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