Aim
Advanced Nanostructured Innovations in Pharmaceutical Sciences covers how nanostructures improve drug delivery, targeting, stability, and therapeutic outcomes. Learn nanoformulation platforms, characterization, safety basics, scale-up concepts, and regulatory-ready documentation through applied case studies and a capstone design project.
Program Objectives
- Nanopharma Basics: why nanosystems change solubility, PK/PD, targeting.
- Platforms: liposomes, polymeric nanoparticles, SLN/NLC, nanoemulsions, dendrimers (overview).
- Targeting: passive vs active targeting, ligand concepts, stimuli-responsive release (intro).
- Characterization: size, PDI, zeta, morphology, loading, release, stability.
- Quality by Design: CQAs/CPPs, design space concepts, risk assessment (intro).
- Scale-Up: reproducibility, sterilization, lyophilization, packaging (overview).
- Safety: biocompatibility, immunogenicity, biodistribution concepts.
- Capstone: design a nanoformulation for a target therapeutic problem.
Program Structure
Module 1: Nanostructures in Modern Pharma
- Drug delivery barriers and why nanosystems help.
- Key outcomes: solubility, stability, circulation time, targeting.
- Clinical translation challenges (overview): scale, safety, variability.
- Case examples: anticancer, vaccines, antimicrobials (overview).
Module 2: Nanostructured Drug Delivery Platforms
- Liposomes and lipid nanoparticles: core concepts.
- Polymeric nanoparticles and micelles: loading and release concepts.
- SLN/NLC and nanoemulsions: stability and formulation logic.
- Dendrimers and inorganic carriers (intro): when used and key risks.
Module 3: Formulation Design (Hands-On Thinking)
- Selecting materials: lipids, polymers, surfactants, PEGylation concept.
- Encapsulation strategies: hydrophobic vs hydrophilic drugs.
- Controlling size and PDI: mixing energy, ratios, process variables.
- Release mechanisms and stability planning.
Module 4: Targeting and Smart Release
- Passive targeting and EPR concept (limitations included).
- Active targeting: ligands, antibodies, peptides (overview).
- Stimuli-responsive systems: pH/redox/temperature/light (intro).
- Crossing biological barriers: mucus, BBB concepts (overview).
Module 5: Characterization and Quality Testing
- Particle size/PDI and zeta potential interpretation.
- Morphology basics: SEM/TEM/AFM concepts (overview).
- Drug loading, encapsulation efficiency, and in-vitro release.
- Stability: shelf-life, aggregation, oxidation, and stress testing.
Module 6: Pharmacokinetics, Biodistribution, and Safety
- ADME changes with nanoparticles (conceptual).
- Protein corona and immune recognition (intro).
- Toxicity basics: hemolysis, cytotoxicity, inflammation markers (overview).
- Preclinical study planning and endpoints (overview).
Module 7: Scale-Up, Manufacturing, and QbD
- Batch vs continuous manufacturing concepts.
- Sterilization, filtration, and aseptic processing (overview).
- Lyophilization and cryoprotectants (intro).
- QbD: CQAs, CPPs, risk tools (FMEA intro), control strategy.
Module 8: Regulatory and Translation (Intro)
- Documentation basics: CMC overview and batch records.
- Analytical methods and release specifications (concepts).
- Regulatory expectations: consistency, safety, stability evidence.
- Ethics and claims: avoiding overstatement in nano-therapeutics.
Final Project
- Pick a therapeutic need: anticancer, antimicrobial, vaccine delivery, chronic disease.
- Design a nanocarrier: material choice + method + CQAs + tests.
- Deliverables: formulation plan + characterization panel + risk register + short report.
Participant Eligibility
- Students and professionals in Pharmacy, Biotechnology, Chemistry, Biomedical/Nanotechnology
- Researchers working on drug delivery and formulation
- Basic pharmaceutics knowledge helpful
Program Outcomes
- Choose suitable nanocarrier platforms for different drugs and targets.
- Plan formulation variables and characterization tests.
- Understand safety, stability, and scale-up constraints.
- Create a capstone nanoformulation design report.
Program Deliverables
- e-LMS Access: lessons, case studies, templates.
- Toolkit: formulation worksheet, CQA/CPP template, characterization checklist, report outline.
- Capstone Support: feedback on formulation plan.
- Assessment: certification after capstone submission.
- e-Certification and e-Marksheet: digital credentials on completion.
Future Career Prospects
- Nanopharmaceutics Research Associate (Entry-level)
- Formulation Scientist (Trainee)
- Drug Delivery R&D Associate
- Analytical Characterization Associate
Job Opportunities
- Pharma R&D: formulation and drug delivery teams.
- Biotech: nanoparticle therapeutics and vaccines.
- CROs: formulation development and characterization services.
- Universities/Research Labs: translational nanomedicine research.
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