About
Epigenome editing is revolutionizing our understanding of gene regulation by enabling precise control over gene expression without making permanent changes to the DNA sequence. This 1-month program covers the fundamentals of epigenetic mechanisms, such as DNA methylation and histone modification, and explores how targeted epigenome editing can be used to modulate these processes. Participants will gain insights into the latest tools, such as CRISPR-based epigenetic modifiers, and their applications in research and disease treatment.
The program emphasizes real-world applications, including using epigenome editing to study gene function, treat genetic disorders, and develop new therapeutic approaches for diseases like cancer and neurological disorders.
Aim
This program aims to introduce participants to the cutting-edge field of epigenome editing, which allows the modification of gene expression without altering the underlying DNA sequence. The program will explore the tools, techniques, and applications of epigenome editing in fields like biomedical research, therapeutics, and personalized medicine.
Program Objectives
- Understand the fundamentals of epigenetics and gene regulation.
- Learn about various tools used for epigenome editing, including CRISPR-based technologies.
- Explore the therapeutic potential of epigenome editing in disease treatment.
- Design and analyze epigenome editing experiments.
- Evaluate the ethical and regulatory aspects of epigenetic modifications.
Program Structure
Week 1: Introduction to Epigenetics and Gene Regulation
Overview of Epigenetics: DNA Methylation, Histone Modification, and Non-coding RNA.
Gene Regulation Mechanisms: Understanding Transcriptional Control.
Introduction to Epigenome Editing Tools: CRISPR-dCas9 and Other Technologies.
Applications of Epigenome Editing in Biomedical Research.
Week 2: Epigenome Editing Techniques and Tools
CRISPR-dCas9 in Epigenome Editing: Mechanisms and Applications.
Design and Development of Epigenetic Modifiers.
Tools for Targeted DNA Methylation and Histone Modification.
Case Studies: Real-World Applications of Epigenome Editing in Research.
Week 3: Therapeutic Applications of Epigenome Editing
Epigenetic Therapies for Cancer: Targeting Aberrant Gene Expression.
Treating Neurological Disorders Using Epigenome Editing.
Personalized Medicine: Tailoring Therapies through Epigenetic Modulation.
Bioinformatics for Epigenetic Data Analysis: Tools and Techniques.
Week 4: Ethical, Regulatory, and Future Directions in Epigenome Editing
Ethical Considerations in Epigenome Editing: Balancing Innovation and Responsibility.
Regulatory Challenges and Compliance in Epigenetic Research.
Emerging Technologies in Epigenome Editing: Beyond CRISPR.
Career Opportunities in Epigenetics and Gene Therapy.
Participant’s Eligibility
- Undergraduate degree in Molecular Biology, Biotechnology, or related fields.
- Professionals in biomedical research or genetic engineering.
- Individuals with a strong interest in gene regulation and therapeutic development.
Program Outcomes
- Mastery of epigenetic mechanisms and their role in gene regulation.
- Ability to design epigenome editing experiments using state-of-the-art tools.
- Knowledge of therapeutic applications of epigenome editing.
- Understanding of bioinformatics tools for analyzing epigenetic data.
- Awareness of ethical and regulatory considerations in epigenetic research.
Program Deliverables
- Access to e-LMS
- Real-Time Project for Dissertation
- Project Guidance
- Paper Publication Opportunity
- Self Assessment
- Final Examination
- e-Certification
- e-Marksheet